Hongyu An1, Andria Ford2, Cihat
Eldeniz1, Katie Vo2, Rosana Ponisio2,
Yasheng Chen1, William Powers1, Jin-Moo Lee2,
Weili Lin1
1University of North Carolina at Chapel
Hill, Chapel Hill, NC, United States; 2Washington University in
St. Louis, St. Louis, MO, United States
Spatial
heterogeneity of tissue perfusion change was detected in acute patients after
tPA treatment. Concurrent development of reperfusion and new hypoperfusion
were observed. Compared to the
reperfused region, the nonreperfused region had a significantly greater MTT
prolongation, suggesting that tissue with a more severe initial injury is
more likely to remain hypoperfused. Moreover, the nonreperfused regions had
the highest risk of infarction, followed by new hypoperfused and reperfused
regions.