Abstract #4405

MRI Assessment of Iron-Mediated Pathology Following Juvenile Traumatic Brain Injury

Lei Huang¹, Arash Adami², Andre Obenaus^1,3

¹Radiation Medicine, Loma Linda University, Loma Linda, CA, United States; ²Neuroscience, University of California, Riverside, Riverside, CA, United States; ³Radiology, Loma Linda University, Loma Linda, CA, United States

In a rat model of graded juvenile traumatic brain injury (jTBI), we characterized iron mediated neuropathology using multi-modal MRI that correlated with histology and tissue iron measures. Our results showed that SWI was sensitive to monitor pathological iron accumulation in vivo following increasing jTBI severity that correlates with increased tissue iron deposition, especially, non-heme iron concentration. The iron-mediated neuropathology was dominant in corpus callosum at this age.