Miyuki Takasu1, Chihiro Tani1,
Masaki Ishikawa1, Keizo Tanitame1, Hiroshi Fukuda1,
Jun Horiguchi1, Akihisa Tamura2, Yoshikazu Nishi3
1Radiology, Hiroshima University
Hospital, Hiroshima, Japan; 2Radiology, Hiroshima Red Cross
Hospital, Hiroshima, Japan; 3Pediatrics, Hiroshima Red Cross
Hospital, Hiroshima, Japan
We
investigated correlations between pituitary volumes measured from 3D
volumetric MR imaging and the severity of the clinical and biochemical
features in 69 patients with growth hormone deficiency. Pituitary volumes of
all patient groups were smaller than the age-matched published norms.
Pituitary volumes of both female groups were significantly smaller than that
of controls. Pituitary volumes of male pubertal or postpubertal group were
significantly larger than that of prepubertal one, but this difference was
not significant between female groups. IGF-1 levels were significantly
correlated with pituitary volumes. LH levels were significantly correlated
with pituitary volumes in male patients.