Cracked Iron Oxide Nanoprticles as T2 Contrast Agents for Magnetic Resonance Imaging

Sung Lan Jeon¹, Min Kyung Chae, Eun Ju Jang, Jee-Hyun Cho, Kwan Soo Hong, Gyunggoo Cho, Chulhyun Lee

Nanoparticles with small size and large surface provide magnetic resonance image with high sensitivity and specificity at low imaging-agent concentration. Metal oxide nanoparticles with hollow spheres can incorporate therapeutic agents into their payloads, enabling simultaneous MRI diagnosis and delivery of drugs to targeted sites. Herein, we report a facile synthesis of nontoxic cracked iron oxide nanoparticles (CIONPs) from hydrophobic FeO nanoparticles (HIONPs) via 3 steps. With complex surface structure, CIONPs showed improved r2 relaxivities compared to hydrophobic FeO nanoparticles (HIONPs). We expect that CIONPs have the potential application as a drug or chemical delivery vehicle because of their cracked spheres. In addition, cellular and in vivo MR imaging study with CIONPs will be tested.