Sophie
Laurent1, Carmen Burta1, Vincent Rerat2,
Jacqueline Marchand-Brynaert2, Luce Vander Elst1,
Robert N. Muller1
1Universit de Mons, Mons, Belgium; 2Universit
catholique de Louvain, Louvain-la-Neuve , Belgium
In
this work, we describe the grafting of a home-made RGD peptidomimetic on ultrasmall
particles of iron oxide (USPIO) coated with 3,3-bis(phosphonate)propionic
acid, and the determination of the grafting rates by X-ray photoelectron
spectroscopy (XPS). The USPIO-g-Mimic have been characterized by photon
correlation spectroscopy (PCS); their magnetometric and relaxometric
profiles, and their capacity to target leukemic cells were also analyzed.