Lindsey Alexandra Crowe1, Frederic Ris2,
Matthieu Lepetit-Coiff1, Christian Toso2, Thierry
Berney2, Jean-Paul Valle1
1Department of Radiology, Geneva
University Hospital, University of Geneva, Faculty of Medicine, Geneva,
Switzerland; 2Cell Isolation and Transplant Center, Department of
Surgery, Geneva University Hospital, Geneva, Switzerland
The
clearance of two injected iron oxide contrast agents was followed by GRE MRI
and T2 decay at 1.5T. Ferucarbotran
(Resovist) was found to clear from the rat liver significantly faster than
ferumoxide (Endorem). The rate of clearance will affect the choice of
contrast agent for serial cell labeling studies where the iron signal from a
rejected cell should be cleared as fast as possible after cell death. T1- and
T2- weighted images and T2 decay curves return to normal within 10 days for
ferucarbotran, but ferumoxide still has a significant effect on the liver
after more than 100 days.