Abstract #4096

Evaluation of Tracer Kinetics Parameters in Brain Gliomas Using Combined T1W and T2*W Contrast-Enhanced Dynamic MR Imaging: Comparison with Pathological Findings

Keiichi Kikuchi¹, Shohei Kouno², Hitoshi Miki¹, Shogo Oda¹, Teruhito Mochizuki¹, Shiro Ohue², Kenya Murase³

¹Radiology, Ehime University, Toon City, Ehime, Japan; ²Neurosurgery, Ehime University, Toon City, Ehime, Japan; ³Medical Engineering, Osaka University, Suita, Osaka, Japan

We evaluated various tracer kinetics parameters of brain gliomas using combined DCE-MRI and DSC-MRI in one examination. The tracer kinetics parameters are high in grade IV gliomas; especially the K1 value has a significant correlation with MIB-1 and MVD. These parameters derived from DSC-MRI and DCE-MRI should be correlated with the tumor vascularity and/or tissue permeability, and will provide additional information for diagnosis and prediction prognosis. Our protocol, which can derive the various tracer kinetics parameters of brain tumors in one examination, will be a promising protocol to evaluate the characteristics of brain tumors.