Fang-Cheng Yeh1, Van Jay Wedeen2,
Wen-Yih Isaac Tseng3
1Department of Biomedical Engineering,
Carnegie Mellon University, Pittsburgh, PA, United States; 2MGH
Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown,
MA, United States; 3Center for Optoelectronic Biomedicine,
National Taiwan University College of Medicine, Taipei, Taiwan
We
present a deconvolution method that estimates fiber orientation distribution
function (ODF) from diffusion ODF. Instead of applying deconvolution on
spherical harmonic parameters, the proposed method performs deconvolution on
the diffusion ODF directly, thereby extending its applicability to diffusion
spectrum imaging (DSI) and generalized q-space imaging (GQI). To test the
performance of the proposed method, we applied it to q-ball imaging (QBI),
DSI, and GQI, with diffusion weighted images acquired by single-shell, grid,
and two-shell sampling schemes, respectively. The result showed that the
fiber ODFs obtained by the proposed method presented sharper contours in all
tested q-space imaging method.