Patricia Dreessen de Gervai1, Victor Yang,
Uta Sboto-Frankenstein, Valery Kupriyanov, Lawrence Ryner
1National Research Council Institute
for Biodiagnostics,
Diffusion
Tensor Magnetic Resonance Imaging (DTI) was used to assess myocardial architecture
in healthy and in injured excised pig hearts in which cryo-ablation was used
to produce targeted infarctions. Using
the lesion and penumbral region as seed points, fibers were not detectable in
the infarct region, FA was reduced and ADC values increased compared to
healthy excised hearts. The penumbral
region contained traceable fibers although FA and ADC values were
affected. This work suggests that the
changes in fiber architecture, FA and ADC involve not only the infarct area
but also the adjacent tissue.