Nicholas P. Blockley1, Ian D. Driver1,
Susan T. Francis1, Penny A. Gowland1
1Sir Peter Mansfield Magnetic Resonance
Centre, School of Physics & Astronomy, University of Nottingham,
Nottingham, United Kingdom
Venous
cerebral blood volume (CBVv) is key to the BOLD response, but could not be
measured directly until the advent of the VERVE technique. We present a new
method for measuring changes in CBVv using hyperoxia. This new method has a
high signal-to-noise ratio enabling high spatial (223mm) and temporal
(TR=2.4s) resolution. In this work we show measurements of relative changes
in CBVv. However with refinements to the acquisition and analysis it will be
possible to measure the percentage change in CBVv.