Valerie Griffeth1,2, Richard Buxton3
1Department of Bioengineering,
University of California, San Diego, La Jolla, CA, United States; 2Medical
Scientist Training Program, University of California, San Diego, La Jolla,
CA, United States; 3Department of Radiology, University of
California, San Diego, La Jolla, CA, United States
We
applied a calibrated-BOLD methodology to assess effects of caffeine
consumption on coupling of CBF and cerebral metabolic rate of O2 (CMRO2)
responses to a visual stimulus. Although the BOLD responses were similar, we
found an increase in *** CMRO2 change after administration of caffeine, both
as a fraction of the current baseline state and in a more absolute sense
referred to the pre-caffeine baseline. More modest changes were found in the
CBF response, leading to a decrease of
the CBF/CMRO2 coupling ratio.