Gaurav Verma1, Scott Logan Lipnick2,
Nagarajan Rajakumar3, Saad Ramadan4, Michael Albert
Thomas3
1Biomedical Engineering, UCLA, Los
Angeles, CA, United States; 2Biomedical Physics, UCLA, Los
Angeles, CA, United States; 3Radiological Sciences, UCLA, Los
Angeles, CA, United States; 4Radiology, Brigham & Women's
Hospital, Cambridge, MA, United States
The
previously-introduced ME-COSI sequence acquires 2D spectra over a 2D spatial
array. ME-COSI reproducibility was investigated in human brain with four
volunteers and eight total scans, and in a physiological gray matter phantom
with thirty-two scans. Data were post-processed and peak integral/volumes
compared to creatine were quantified. Measured coefficients of variation
across all scans ranged from 4-17% for single subject in vivo, 7-26% for
multiple subjects and 6-25% for in vitro studies, at half the voxel volume.
This is comparable to the performance reported from existing single-voxel 2D
MRS methods.