Towards a Localized Low Power Adiabatic 2D TOCSY for In-Vivo Use on Clinical Platforms

Ovidiu Cristian Andronesi¹, Saadallah Ramadan², Carolyn E. Mountford², A Gregory Sorensen¹

Two-dimensional spectroscopy is important for unambiguous assignment of overlapping metabolites and could be more efficient than 1D spectral-editing. 2D TOCSY (TOtal-Correlation-SpectroscopY) is one of the most powerful experiments that reveals the full spin connectivity, but demands for a sustained spin-lock can prevent in-vivo applications. 1D spectral-edited TOCSY was demonstrated recently, although an in-vivo 2D TOCSY has not been realized yet. We propose a modified 2D version of the localized TOCSY, including a z filter and the use of gradient offset independent adiabaticity (GOIA) pulses to reduce SAR. Simulations and phantom measurements on a 3T Siemens MR clinical scanner are presented.