NMR Spectroscopy Based Study of Physiological Perturbations During Recurrence of Symptoms in Radiation Sickness

Poonam Rana¹, Ahmad Raza Khan¹, M Memita Devi¹, Sunil Pal², Subash Khushu¹

Regular monitoring of irradiated patient is essential for clinical management during illness phase of radiation sickness. The present study has been designed to explore metabolic perturbation in mice urine after three weeks of irradiation. The results based on urine NMR spectra analysis exhibited an altered energy, amino acid and gut microflora metabolism which could indicate renal and liver dysfunction. These changes could be the consequence of radiation induced damage to physiological systems during recurrence of clinical symptoms after recovery period. The information attained from the study along with biochemical assays could be very useful in assessing the organ dysfunction during radiation sickness.