Sonia
Gandhi1, Memita Devi1, Shubhra Chaturvedi2,
Subash Khushu1
1NMR Research Centre, Institute of
Nuclear Medicine and Allied Sciences, Delhi, India; 2Division and
Cyclotron & Radiopharmaceutical Sciences, Institute of Nuclear Medicine
and Allied Sciences, Delhi, India
Cold
stress is responsible for affecting multiple biochemical regulatory systems
& triggering cardiovascular & respiratory disorders, cognitive
impairment, anxiety. Present study investigates the changes in metabolic
profiles of urine in rats due to acute cold stress using NMR &
multivariate statistical analysis (PCA). Results indicate up regulation of
TCA cycle decreasing pyruvate, citrate, 2-oxoglutrate, succinate &
fumarate concentration. Creatinine & Hippurate levels were reduced
altering gut microbiota. Decreased aromatic amino acids & TMAO also
supports kidney dysfunction. Noninvasive monitoring of various biochemical
pathways can be done & these results can be used to develop strategies to
sustain cold stress.