Neurotransmitter Profiling at 3T Using GABA Optimized PRESS Sequence

Antonio Napolitano¹, Walter Kockenberger², Dorothee P. Auer¹

The spectroscopic detection of GABA is still challenging due to its low concentration, and the fact that all GABA peaks are overlapped by much stronger metabolite resonances at the field strength accessible for clinical studies. This study aims to simultaneously detect GABA as well as Glu, Gln pools using a standard PRESS localization pulse sequence with optimized timing parameters.