Yan Li1, Janine M. Lupo1, Duan Xu1,
Douglas A.C. Kelley2, Sarah J. Nelson1,3
1Department of Radiology and Biomedical
Imaging, University of California, San Francisco, CA, United States; 2Applied
Science Laboratory, GE Healthcare, San Francisco, CA, United States; 3Department
of Bioengineering & Therapeutic Sciences, University of California, San
Francisco, CA, United States
The
availability of whole body MR scanners with field strengths of 7 Tesla offers
the potential of higher SNR and better spectral resolution, but also introduces
complications, such as the presence of increased sidebands from unsuppressed
water. The purpose of this study was to evaluate the efficacy of VAPOR water
suppression and to assess the improvements in the accuracy of metabolite
quantification compared to conventional water suppression with CHESS. The
data acquired using VAPOR water suppression have smaller residual water
signals, less gradient-induced water sidebands, lower CRLB and coefficients
of variance compared to that acquired using CHESS. VAPOR suppression is
therefore a valuable tool for improving the accuracy of metabolite
quantification.