Full 1H to 31P Polarization Transfer on 7 Tesla.

Wybe van der Kemp¹, Vincent Boer¹, Peter Luijten¹, Dennis Klomp¹

Full 1H to 31P polarization transfer was shown for phosphocholine and phosphoethanolamine, using the sRINEPT sequence. The sRINEPT sequence is a RINEPT in which the first inversion pulse on the proton channel is a selective inversion pulse, thus preventing polarization transfer losses caused by inter-proton coupling. Quantum chemical simulations on these compounds and their glycerol-derivatives shows that polarization transfer is at a maximum within an offset frequency range of 0.2 ppm for the selective pulse. Measurements on a phosphocholine phantom agree well with the simulations. Implementation of (segmented) BIR4 pulses on the 31P channel enhances the signal further.