Florian
Wiesinger1, Isabelle Miederer2, Marion I. Menzel1,
Eliane Weidl2, Martin Janich1,3, Jan-Henrik
Ardenkjaer-Larsen4, Markus Schwaiger2, Rolf F. Schulte1
1Imaging Technologies, GE Global
Research, Munich, Germany; 2Institute for Nuclear Medicine,
Technical University Munich, Munich, Germany; 3Department of
Chemistry, Technical University Munich, Munich, Germany; 4MST-ASL
MR, GE Healthcare, Copenhagen, Denmark
In
this work, the two-side, kinetic exchange model is applied for hyperpolarized
13C pyruvate in a way such that it does not involve the pyruvate input
function. In combination with
time-resolved IDEAL spiral CSI, the method is demonstrated to generate
spatially-resolved rate constant maps.
Ultimately, the method might be particularly useful for the
non-invasive localization and characterization of tumors and their response
to therapy.