Peter J. Shin1,2, Simon Hu2,
Peder E. Z. Larson2, Kayvan R. Keshari2, John
Kurhanewicz1,2, Daniel B. Vigneron1,2
1Joint Graduate Group in
Bioengineering, University of California at San Francisco & Berkeley, San
Francisco, CA, United States; 2Department of Radiology and
Biomedical Imaging, University of California at San Francisco, San Francisco,
CA, United States
13C-fructose
has been recently proposed as a novel hyperpolarized 13C probe.
The short T1 of 13C-fructose could impose additional
challenges in designing data acquisition strategies. Here, we have optimized
an acquisition scheme using a specialized simulation tool and showed that a T1
compensated RF excitation scheme together with compressed sensing can yield
minimized spatial blurring with high SNR enough for in vivo 13C-fructose metabolic imaging.