Lanette Friesen Waldner1,2, Timothy Scholl3,
Albert Chen4, Brian Rutt, 1,5, Charles McKenzie,
12
1Imaging Research Laboratories, Robarts
Research Institute, London, ON, Canada; 2Medical Biophysics, The
University of Western Ontario, London, ON, Canada; 3Physics and
Astronomy, The University of Western Ontario, London, ON, Canada; 4GE
Healthcare, Toronto, ON, Canada; 5Diagnostic Radiology and Richard
M Lucas Center for Imaging, Stanford University, Stanford, CA, United States
The
addition of small quantities of gadolinium based contrast agents (GBCA) to 13C-enriched
samples containing trityl radical significantly increases the
hyperpolarisation that can be obtained via dynamic nuclear polarisation. This study examined the effects of several
contrast agents on T1 in
solution and on relative hyperpolarisation in the solid state in [1-13C]-labeled
pyruvic acid. T1 decreased with increasing contrast agent
concentration with all contrast agents except Teslascan. Dotarem and ProHance showed a slight
decrease in T1. MultiHance showed the largest increase in
hyperpolarisation and the largest decrease in T1. The choice
of contrast agent may depend on the application.