Mary C. Mahoney1, Jing Huei Lee2,
Wen Jang Chu2, John M. Pearce2, Kim M. Cecil3,
Stephen M. Strakowski2, Richard A. Komoroski2
1Radiology, University of Cincinnati,
Cincinnati, OH, United States; 2Center for Imaging Research,
University of Cincinnati, Cincinnati, OH, United States; 3Radiology,
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
In vivo 1H MRS of
breast cancer lesions can detect a signal assigned to total choline (tCho),
which arises from a variety of choline-containing metabolites. The
contribution of each metabolite to the increased tCho peak in vivo is not known. Here we report in vitro 1H NMR
spectroscopy results on fine-needle aspirate (FNA) biopsies of lesions from
breast cancer patients, several of whom were also studied by in vivo MRS. Phosphocholine was
usually the major metabolite, whereas the contribution of
glycerophosphocholine varied substantially, and that of Cho was always minor.