Detection Of Cancer In Cervical Tissue Biopsies Using Mobile Lipid Resonances Measured With Diffusion-Weighted 1h Magnetic Resonance Spectroscopy

Dominik Zietkowski¹, Robert L. Davidson¹, Thomas R. Eykyn¹, Sonali S. De Silva¹, Nandita M. deSouza¹, Geoffrey S. Payne¹

An optimised diffusion-weighted stimulated echo sequence with bipolar gradients attenuated low molecular weight metabolites in cervical cancer tissue samples giving improved visibility and characterisation of mobile lipid resonances (MLR). Linear discriminant analysis (LDA) of MLR peaks almost completely separated cervical biopsies containing cancer from those that did not, reflecting underlying differences in MLR composition. Generated Receiver Operating Characteristic (ROC) curves and calculated area under the curve (0.962) validated high sensitivity and specificity of the technique.