David John Lomas1, Richard T. Black1,
Andrew J. Patterson1, Kieren G. Hollingsworth1, Susan
Davies2, Graeme J. Alexander3, Mike E. Allison3,
Neville V. Jamieson4, Alex E. Gimson3, Raaj K.
Praseedom4, Chris J. Watson4
1Radiology, University of Cambridge
& Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 2Pathology,
University of Cambridge & Addenbrooke's Hospital, Cambridge,
Cambridgeshire, United Kingdom; 3Hepatology, University of Cambridge
& Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 4Surgery,
University of Cambridge & Addenbrooke's Hospital, Cambridge,
Cambridgeshire, United Kingdom
The
results of rapid MRI based measurement of donor graft steatosis immediately
prior to orthotopic liver transplantation in 49 patients were correlated with
surgical and histopathology estimates, first week graft performance and 3 and
12 month outcomes. MR measurements correlated significantly with the other
steatosis estimates but did not correlate with early serum performance
markers. Both MRI and pathology estimates indicated significantly increased
graft steatosis in those grafts failing at 3 months but not at 12 months.
Such MRI based measurements may be a valuable tool for further investigating
the impact of graft steatosis on transplant outcomes.