Matthew S. Fox1,2, Alexei Ouriadov1,
William Dominguez-Viqueira1,3, Marcus Couch1,2, Giles
E. Santyr1,3
1Imaging, Robarts Research Institute,
London, Ontario, Canada; 2Physics and Astronomy Dept, University
of Western Ontario, London, Ontario, Canada; 3Medical Biophysics,
University of Western Ontario, London, Ontario, Canada
Hyperpolarized
129Xe is a novel gaseous contrast agent which also dissolves in
the lung parenchyma and blood compartments, offering an interesting palette
of potential biomarkers of pulmonary disease. 129Xe signals from
the dissolved compartments have different chemical shifts and can be
selectively saturated and allowed to recovery as a function of delay time as
in the chemically selective saturation recovery (CSSR) technique. We collected CSSR data and 3D volumes from
rat lungs in-vivo and explore both the