Masaru Ishii1,2, Kiarash Emami2,
John M. Woodburn2, Stephen J. Kadlecek2, Elaine Chia2,
Jianliang Zhu3, Stephen Pickup2, Yi Xin2,
Rahim R. Rizi2
1Department of Otolaryngology, Johns
Hopkins University, Baltimore, MD, United States; 2Department of Radiology,
University of Pennsylvania, Philadelphia, PA, United States; 3Department
of Surgery, University of Pennsylvania, Philadelphia, PA, United States
The
sensitivity of two HP 3He MRI-based measurements, gas diffusivity
and ventilation, to elastase-induced changes in a murine model of emphysema
is studied in this work. The motivation is primarily the increasing interest
in assessments of pulmonary disease models and assessments of therapeutic
interventions in transgenic murine disease models, which require that
functional and structural lung imaging techniques be translated to a smaller
scale. We present a predictive model
for calculating the probability that a section of lung originated from a
diseased animal.