Sang-Young Kim1,2, Chi-Bong Choi3,
Hyun-Sung Lee4, Sung-Ho Lee5, Dong-Cheol Woo1,2,
Bo-Young Choe1,2
1Department of Biomedical Engineering,
The Catholic University of Korea, Seoul, Korea, Republic of; 2Research
Institute of Biomedical Engineering, Seoul, Korea, Republic of; 3Department
of Radiology, Kyunghee University Medical Center, Seoul, Korea, Republic of; 4Korea
Basic Science Institute, Korea, Republic of; 5Department of
Veterinary Surgery, Konkuk University, Seoul, Korea, Republic of
Animal
models for depression are indispensable tools in the search to identify new
antidepressant drugs. The forced swimming test (FST) is the most widely used
tool for assessing antidepressant activity in rodents. Few studies have been
performed proton spectroscopy to assess antidepressant effects on brain
metabolism of rat exposed to the FST. The in vivo proton spectra quantified
by LCModel revealed that myo-inositol metabolic level in left dorsolateral
prefrontal cortex of rat was significantly altered in both FST and
desipramine treated group. Our findings suggest a possible role of
myo-inositol within the left DLPFC of rat model for depression.