Sang-Young Kim1,2, Chi-Bong Choi3,
Yun-Jung Lee4, Hyeonjin Kim4, Do-Wan Lee1,2,
Dong-Cheol Woo1,2, Jeong-Ho Chae5, Bo-Young Choe1,2
1Department of Biomedical Engineering,
The Catholic University of Korea, Seoul, Korea, Republic of; 2Research
Institute of Biomedical Engineering, Seoul, Korea, Republic of; 3Department
of Radiology, Kyunghee University Medical Center, Seoul, Korea, Republic of; 4Gachon
University of Medicine and Science, Incheon, Korea, Republic of; 5Department
of Psychiatry, The Catholic University of Korea, Seoul, Korea, Republic of
Until
recently, no data are available about the behavioral and simultaneous
non-invasive measurements of neurochemial responses following antidepressant
treatment in mice FST model. In this study, in vivo 1H-MRS at 9.4 T was used
to examine the effects of desipramine (DMI) pretreatment on behavioral and
regional neurocheimal responses of C57BL/6 mice brain. We found significant
behavioral changes as well as metabolic alterations of glutamate and
myo-inositol by the DMI pretreatment. Our results suggest that glutamatergic
activity and glial cell dysfunction contribute to pathophysiological
mechanisms underlying depression and that modulation of synaptic
neurotransmitter concentrations represent invaluable targets for
antidepressant drug development.