Comparison Between 2dTCA and EEG/fMRI to Localize Interictal Activity in Temporal Lobe Epilepsy

Victoria L. Morgan¹, Xiaoyun Liang¹, John C. Gore¹, Bassel Abou-Khalil²

Functional MRI (fMRI) has the potential for non-invasively localizing interictal epileptic activity more accurately than other clinical methods. Currently the gold standard for detecting the timing of interictal activity during the fMRI scan is simultaneous electroencephalography (EEG). The objective of this work is to compare a data-driven method, 2dTCA, to EEG/fMRI in temporal lobe epilepsy. Overall, there was good qualitative agreement between the two methods with the 2dTCA maps showing more mesial temporal activation concurring with the presumed epileptogenic region in these patients, without the need for the additional hardware, software, analyses and scalp EEG spikes required for EEG/fMRI.