Abstract #2076

Lesion Recognition in Multiple Sclerosis: A Sequence Comparison and Quantification Study at 3T

Tobias Kober^1,2, Cristina Granziera^3,4, Delphine Ribes^1,2, Patrick Browaeys⁵, Myriam Schluep⁶, Katrin Wohlfarth⁷, Reto Meuli⁵, Gunnar Krueger²

¹Laboratory for functional and metabolic imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; ²Advanced Clinical Imaging Technology, Siemens Suisse SA - CIBM, Lausanne, Switzerland; ³Department of Neurology, Hpitaux Universitaires de Genve, Lausanne, Switzerland; ⁴Brain and Mind Institute, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; ⁵Department of Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; ⁶Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; ⁷H IM MR PLM AW Neurology, Siemens AG, Erlangen, Germany

Detection and radiological characterisation of multiple sclerosis (MS) lesions is an essential part both of clinical diagnosis and MS research. Ten early-stage MS patients and ten controls were included in this study aiming at (i) comparing five different high-resolution imaging sequences (FLAIR, MP-RAGE, DIR, SPACE, MP2RAGE) and (ii) quantifying T1 relaxation times of lesions with respect to their location in the brain. Results suggest that the DIR sequence is the most sensitive for total lesion count, followed by the MP2RAGE. Confirming previous studies, T1 relaxation times were found to be overall prolonged.