Evaluating MACC for Improved MS Rater Agreement

David S. Wack¹, Michael G. Dwyer¹, Niels Bergsland¹, Sara Hussein¹, Robert Zivadinov¹

The software method of Minimum Area Contour Change (MACC) is evaluated for use to improve same scan inter-rater agreement for the delineation of T2 hyper-intense MS lesions; and for the application of ROIs to follow up time points. The MACC method improves inter-rater agreement, and performs about on par with another rater for the purpose of drawing lesion ROIs on a follow-up scan.