Live Eikenes1,
Jon Skranes2, Ann-Mari Brubakk2, Asta Hberg3
1Department of circulation and medical
imaging, Norwegian University of Science and Technology, Trondheim, Norway; 2Department
of Laboratory Medicine, Children's and Women's Health, Norwegian University
of Science and Technology, Trondheim, Norway; 3Department of
Neuroscience, Norwegian University of Science and Technology, Trondheim,
Norway
Preterm
birth with very low birth weight (VLBW, ≤ 1500 g) is associated with
reduced white matter integrity and connectivity in childhood and adolescence.
These changes in white matter are correlated to motor, sensory and
neuropsychological impairments. This study demonstrates that preterm birth
with VLBW results in significant and long-term irreversible changes in white
matter microstructure that may interfere with neuropsychological functioning.
Lower birth weight and perinatal problems requiring prolonged treatment on
mechanical ventilator and/or intensive care have permanent negative effects
on white matter integrity.