Dynamic Changes in Causal Strength in Memory Encoding Networks in Alzheimers Disease Detected by Granger Causality Analysis

Guangyu Chen¹, B. Douglas Ward¹, Shi-Jiang Li¹

A quantitative Granger causality analysis, which can measure the causal strength among different time series, was employed to identify and quantify the directional hippocampus and default model network in cognitively normal subjects, and detect the changes in the directional network in AD patients. Interestingly in AD subjects, the functional afferents of parahippocampal gyrus is significantly decreased but the efferents of that are increased. And the abnormal network are correlated with abnormal behaviors.