Abstract #1948

Fully-Automated MRI Quantification of Lateral-Ventricle Volume and Volume-Change in Patients with Alzheimers Disease

Zografos Caramanos^1,2, Vladimir S. Fonov³, Jacqueline T. Chen,^2,3, Simon J. Francis,^2,3, Alexandre Carmel-Veilleux^3,4, Sridar Narayanan,^2,3, D Louis Collins³, Douglas L. Arnold,^2,3

¹McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec , Canada; ²NeuroRx Research, Montreal, Quebec, Canada; ³McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; ⁴NeuroRx Research, Montreal, Quebec , Canada

Precise and accurate quantification of the volume, and longitudinal change in volume, of the lateral ventricles (LV) based on MRI data is an important goal in understanding the natural progression of neurodegenerative disorders such as Alzheimers disease (AD) and multiple sclerosis. In the present study, we provide evidence from 270 AD patients for the accuracy of a novel, fully-automated, MRI-based technique for LV segmentation. Furthermore, we provide preliminary evidence (from a subset of 33 of these patients) for the validity and precision of two novel, fully-automated, MRI-based techniques for the estimation of longitudinal change in LV volume.