Abstract #1947

Pulsed Arterial Spin Labeling Perfusion in Healthy Aging and Early Dementia

Christine Preibisch¹, Annette Frschler¹, Afra Wohlschlger¹, Christian Sorg², Timo Grimmer², Hans Frstl², Alexander Kurz², Claus Zimmer¹, Panagiotis Alexopoulos²

¹Abteilung fr Neuroradiologie, Klinikum rechts der Isar der Technischen Universitt Mnchen, Munich, Germany; ²Klinik und Poliklinik fr Psychiatrie und Psychotherapie, Klinikum rechts der Isar der Technischen Universitt Mnchen, Munich, Germany

Problem: PASL was used to study cerebral perfusion changes in patients with MCI and AD. Methods: Resting CBF maps were obtained from 16 young (3010a) and 15 elderly (655a) cognitively normal controls, 13 patients with MCI (699a) and 7 patients with mild dementia in AD (70.911.2a). Results: Hypoperfusion was detected in parietal cortex and right angular gyrus when patients were compared to controls. A significant perfusion decrease in parietal cortex and left caudate was also detected in elderly compared to young controls. Conclusion: This suggests that PASL is capable to investigate the transition from normal ageing to dementia.