Didem Bilensoy Aksoy1, Roland Bammer2,
Michael Mlynash1, Sandeep N. Gupta3, Ryan W. Snider1,
Irina Eyngorn1, Chitra Venkatasubramanian1, Nancy
Fischbein2, Christine A.C. Wijman1
1Department of Neurology and
Neurological Sciences, Stanford Stroke Center, Stanford University, Palo
Alto, CA, United States; 2Department of Radiology, Stanford
University, Palo Alto, CA, United States; 3Global Research Center,
General Electric, Niskayuna, NY, United States
Dynamic
Contrast-Enhanced (DCE) MRI was used as a tool to assess and quantify
blood-brain barrier (BBB) injury following spontaneous intracerebral
hemorrhage (ICH). BBB permeability and
its relationship with perihematomal tissue diffusivity, a sign of edema
severity, were studied. Significantly increased BBB permeability in the
region immediately surrounding the hematoma was observed. BBB leakage
correlated with diffusivity in the region surrounding the hematoma.