Otto Mlby Henriksen1, Henrik B.W. Larsson1,
Adam E. Hansen1,2, Egill Rostrup1
1Functional Imaging Unit, Dept. of
Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Glostrup,
Denmark; 2Dept. of Radiology, Glostrup Hospital, Glostrup, Denmark
Partial
volume effect (PVE) may cause erroneous determination of the arterial input
function (AIF) leading to inaccurate measurements of cerebral blood flow
(CBF) in bolus tracking MRI. Analyzing
dynamic contrast enhanced CBF measurements in healthy subjects, we studied
the effect of different PVE correction methods on 1) agreement of CBF using
AIF from either the right or the left internal carotid artery 2)
repeatability of repeated measurements. Scaling of the AIF to the venous
output function, either by least square fit or area under the concentration
curves yielded better agreement and repeatability compared to cerebral blood
volume correction methods.