Whole Body TOF Mouse Magnetic Resonance Angiography

William Lefranois¹, Wadie Ben Hassen, Stphane Sanchez, Jean-Michel Franconi, Eric Thiaudire, Sylvain Miraux

Vascular diseases, particularly atherosclerosis, are a major health problem in developed countries. In some cases, stenosis can become critical and cause coronary heart disease necessitating surgical interventions. Therapy planning in patients with multiple stenosis could be facilitated by using whole body angiography. MR angiography (MRA) method currently used on human, is first-pass MRA using a Gadolinium contrast agent. However, this method can not be used on small animal models. This study aimed to develop a fast Time-of-Flight-MRA method able to screen the whole body in reasonable acquisition times and assess the degree and extent of stenosis.