Abstract #1320
The
Effects of Fasting on Myocardial Lipid Content in Fatty Acid β-Oxidation
Deficient Mice Studied with in Vivo
1H-MRS
Adrianus Johannes Bakermans1, Sander M.
Houten2, Tom R. Geraedts1, Michel van Weeghel2,
Klaas Nicolay1, Jeanine J. Prompers1
1Biomedical Engineering, Eindhoven University
of Technology, Eindhoven,
Netherlands; 2Laboratory
Genetic Metabolic Diseases, Academic Medical Centre, Amsterdam, Netherlands
A
respiratory gated, cardiac triggered PRESS 1H-MRS sequence was
used to investigate effects of fasting on lipid content in the long chain
acyl-coenzyme A dehydrogenase knockout (LCAD-/-) mouse heart. Left
ventricular (LV)
function and morphology were assessed using cine MRI. LV
mass normalized to body weight was larger in LCAD-/- mice than in
controls, indicating LV
hypertrophy. There was a trend for a decrease in ejection fraction after
fasting, accompanied by increased lipid content in LCAD-/- mice
compared to controls. It remains to be established whether there is a causal
relationship between increased myocardial lipid content and decreased cardiac
function.
