Xiangzhi Zhou1, Veronica Rundell1,
Ying Liu1, Richard Tang1, Rachel Klein1,
Shivraman Giri2, Saurabh Shah3, Sotirios A. Tsaftaris1,
Sven Zuehlsdorff3, Orlando Simonetti2, Debiao Li1,
Rohan Dharmakumar1
1Northwestern University, Chicago, IL,
United States; 2Ohio State University, Columbus, OH, United
States; 3Siemens Medical Solutions USA, Inc., Chicago, IL, United
States
The
biophysical mechanisms contributing to myocardial edema contrast in
T2-weighted STIR images was studied using dogs subjected to ischemia-reperfusion
injury. It is shown that in addition to T2-weighting, edema detection in
acute myocardial infarcts with T2-weighted STIR images have substantial
weighting from proton density changes. This finding suggests that myocardial
edema detection sensitivity is enhanced when acquisition strategies permit
sensitivity to proton density, as well as T2 changes.