Benjamin Waghorn1,2, Wen Li3,4,
Xin Yu3,4, Tom C.-C. Hu1,2
1Department of Radiology, Medical
College of Georgia, Augusta, GA, United States; 2Nuclear and
Radiological Engineering and Medical Physics Programs, Georgia Institute of
Technology, Atlanta, GA, United States; 3Department of Biomedical
Engineering, Case Western Reserve University, Cleveland, OH, United States; 4Case
Center for Imaging Research, Case Western Reserve University, Cleveland, OH,
United States
Intracellular
calcium overloading and structural changes are known to occur in the
post-myocardial infarction (MI) heart. This study demonstrates the use of
combined cardiac T1-mapping manganese-enhanced MRI and DTI in a
mouse MI model to examine the relationship between indirect Ca2+
handling and structural modification during the myocardial remodeling
process. Decreased Mn2+ uptake was observed for the infracted
tissue, as well as the ischemic peri-infarct tissue, with a decrease in
diffusivity and an increase in diffusion anisotropy also observed in the
infarct hearts. Results from this study could provide a method for monitoring
the salvageability of the peri-infarcted zone.