Comparison of Gd-BOPTA and Gd-DPTA Late Gadolinium Enhancement for Visualizing Scar, Using Valve Enhancement as a Surrogate for Scar Adjacent to Blood

Dana C. Peters¹, Reza Nezafat¹, Peng Hu¹, Yuchi Han¹, Warren J. Manning^1,2

The CNR (blood-fibrosis) of Gd-BOPTA was compared to Gd-DTPA, using a high resolution late gadolinium enhancement technique with 0.2mmol/kg injection and a 15-40 minute delay. Eighteen patients were imaged with Gd-BOPTA, 8 of which were imaged with Gd-DTPA at another time point. The valves were studied as a surrogate for scar which adjacent to blood. The valve enhancement was greater using Gd-DTPA (p<0.05), Blood SNR was greater with Gd-BOPTA (p<0.05), and fibrosis blood CNR (measured in the valves) was greater for Gd-DTPA (p<0.05). Gd-DTPA outperformed Gd-BOPTA at this dose for visualizing the valve enhancement.