Najmeh Khalili-Mahani1,2, Mathiass J. P. Van
Osch1, Remco W. M Zoethout3, Evelinda Baerends1,
Mark A. Van Buchem1, Joop M. A. Van Gerven3, Serge A.
R. B. Rombouts1,2
1Leiden University Medical Center,
Department of Radiology, Leiden, Netherlands; 2Leiden Institute
for Brain and Cognition, Department of Psychology, Leiden, Netherlands; 3Center
for Human Drug Research, Leiden University Medical Center, Leiden,
Netherlands
In
a within-subject placebo-controlled pharma-fMRI study, we use
pseudo-continuous ASL to show localized and drug-specific changes in CBF in
response to dose-controlled infusion of morphine and alcohol. Results
correspond to variations observed in the resting-state BOLD fluctuations in the
same study.