Najmeh Khalili-Mahani1,2, Remco W. M
Zoethout3, Christian F. Beckmann4,5, Evelinda Baerends6,
Roelof P. Soeter, 2,6, Marike de Kam3, Mark A. Van
Buchem6, Joop M. A. Van Gerven3, Serge A. R .B.
Rombouts, 2,6
1Leiden University Medical Center,
Department of Radiology, Leiden , Netherlands; 2Leiden Institute
for Brain and Cognition, Department of Psychology, Leiden, Netherlands; 3Center
for Human Drug Research, Leiden University Medical Center, Leiden,
Netherlands; 4Oxford University, Oxford, United Kingdom; 5Imperial
College London, London, United Kingdom; 6Leiden University Medical
Center, Department of Radiology, Leiden, Netherlands
Using
state of art pharmacological infusion techniques in a placebo-controlled
two-way (treatment by time: 3x7) repeated measure study we show specific and
meaningful variations in resting-state brain connectivity in response to
dose-controlled administration of morphine and alcohol