In Vivo Characterisation of Orthotopic Prostate Tumor and Healthy Rat Prostate Metabolism Using 1H MRS at 4.7 T

Xavier Tizon¹, Peggy Provent¹, Sebastien Parfait², Gilles Crehange³, Johel Miteran², Philippe Genne¹, François Brunotte², Olivier Duchamp¹, Paul Michael Walker²

¹H-MRS appears to be a sensitive technique to detect prostate cancer in the clinic. The aim of this study was to establish an experimental setting to monitor the metabolism of orthotopic prostate cancer in rats, as a candidate biomarker of efficacy for anticancer drugs.