Neurochemical Profiles of Several Brain Regions Determined by Short-Echo, 1H MRS at 7T

Uzay Emrah Emir¹, Melissa Terpstra¹, Ivan Tkac¹, Gulin Oz¹

All studies that obtained a neurochemical profile from short echo ¹H MRS at 7T so far utilized data from the occipital lobe acquired with surface coils. In this study, we demonstrate the feasibility of acquiring and quantifying short-echo (TE = 8 ms), single voxel STEAM spectra by utilizing 16 channel transmit/receive transmission line coils and B₁ shimming at 7T. Representative spectra and neurochemical profiles are reported from brain regions that are of interest for various neurological disorders, such as the frontal white matter, posterior cingulate, putamen, and the substantia nigra.