Changho Choi1, Aditya Patel1
1Advanced Imaging Research Center,
University of Texas Southwestern Medical Center, Dallas, TX, United States
Serine
(Ser) in human brain, which has coupled proton resonances at 3.98, 3.94, and
3.83 ppm, is difficult to measure because of its relatively low concentration
(~0.5 mM) and the spectral overlap with the creatine (Cr) 3.92 ppm
resonance. Constant-TE difference
editing strategies for detection of Ser at 3T have been explored. Echo time dependence of the Ser multiplet
was investigated, with density-matrix simulation, for point-resolved
spectroscopy and triple refocusing. The Ser multiplets in sub- and
difference-spectra were in good agreement between simulation and phantom
experiments. In vivo feasibility of the difference editing methods is discussed
with results from a phantom with physiological concentrations of Ser and Cr.