Marine Beaumont1, Marc G. DuVal2,
Yasir Loai3, Walid A. Farhat3, George K. Sndor2,
Hai-Ling Margaret Cheng1,4
1The Research Institute and Diagnostic
Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Department
of Oral and Maxillofacial Surgery, University of Toronto, Toronto, Ontario,
Canada; 3Division of Urology, The Hospital for Sick Children,
Toronto, Ontario, Canada; 4Department of Medical Biophysics,
University of Toronto, Toronto, Ontario, Canada
Tissue
repair plays a key role in successful tissue regeneration and involves
various simultaneous processes. In bone regeneration, bone growth in a defect
occurs only in the absence of early fibrous scar formation or collapse of
surrounding tissues into the defect. In this study, a tissue-engineered
construct is inserted into a defect in the rabbit calvarium to provide a
3-dimensional resorbable scaffold that maintains a space for bone growth.
Multicomponent T2 measurements are performed to characterize and
differentiate tissue repair from normal construct resorption.