Abstract #0744

Evaluation of Liver Regeneration in Human After Portal Vein Embolization and Partial Hepatectomy Using in Vivo 1H Decoupled - 31P Magnetic Resonance Spectroscopy Imaging

Jing Qi¹, Amita Shukla-Dave, Yuman Fong², Mithat Gnen³, Lawrence H. Schwartz⁴, William M. Jarnagin², Jason A. Koutcher, Kristen L. Zakian¹

¹Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; ²Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; ³Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; ⁴Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

To compare the metabolic feature of hepatic regeneration stimulated by portal vein embolization (PVE) and partial hepatectomy (PH), liver 1H-decoupled 31P-MRSI data acquired from 8 healthy subjects, 6 patients at 48 hours following PVE and 4 patients at 48 hours following PH were analyzed. PH showed similar PME/NTP value as PVE, but significantly higher than control group. PH had significantly elevated PME/PDE, PE/NTP and PE/PC ratios but lower PC/NTP ratio compared to PVE and control subjects. The biochemical difference at 48 hours following PH and PVE indicated that hepatic regeneration process after PVE is not as strong as PH.