Dissociation of Anterior Cingulate Glutamate and Induced Theta EEG Activity in Schizophrenia.

Antonio Napolitano¹, Kathrin Doege², Mallikarjun Pavan², Peter Liddle², Dorothee P. Auer¹

The glutamate hypothesis stimulated over the last two decades several MRS studies to research alterations of glutamate levels in schizophrenia. In this study, we used a combined EEG/MRS protocol to investigate whether prefrontal glutamate levels are altered in patients with early schizophrenia and whether there is an interrelation between glutamate and theta activity in schizophrenia.